Journal of Vector Borne Diseases

REVIEW ARTICLE
Year
: 2022  |  Volume : 59  |  Issue : 1  |  Page : 1--11

An analytical review of vector- and pathogen-based transmission-blocking vaccine for malaria control


Renu Jakhar1, Neelam Sehrawat2, SK Gakhar1 
1 Centre for Medical Biotechnology, Maharshi Dayanand University, Rohtak, Haryana, India
2 Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana, India

Correspondence Address:
Renu Jakhar
Centre for Medical Biotechnology, Maharshi Dayanand University, Rohtak-124001, Haryana
India

Malaria is a vector borne disease, considered to be one of the most serious public health problems. The present review focused on the blocking of parasite development in mosquito vectors; one broad strategy for achieving this is Transmission Blocking Vaccines (TBV). The TBVs usually rely on immunization of vertebrate hosts with molecules derived from the vector or pathogen to reduce pathogen transmission from infected to uninfected hosts. Most of the studies on the TBVs are based on the antibodies targeted against the surface antigens of sexual stages of malaria parasite, but it is meagre to develop mosquito-based vaccine in this regard. Vector-based TBVs include surface proteins that are expressed by the mosquito midgut digestive enzymes which are induced upon blood-feeding, and receptors expressed on the epithelial line of the tissue. Many proteins are reported that can act as candidates for transmission-blocking vaccines. This review aims to summarize the vector midgut-based proteins identified till date, that can block the development and maturity of sexual stages of the parasite within mosquitoes as targets for transmission-blocking vaccine development. The TBVs intervention can block transmission of different malaria parasite species in various species of mosquitoes with future application perspective worldwide.


How to cite this article:
Jakhar R, Sehrawat N, Gakhar S K. An analytical review of vector- and pathogen-based transmission-blocking vaccine for malaria control.J Vector Borne Dis 2022;59:1-11


How to cite this URL:
Jakhar R, Sehrawat N, Gakhar S K. An analytical review of vector- and pathogen-based transmission-blocking vaccine for malaria control. J Vector Borne Dis [serial online] 2022 [cited 2022 Jun 27 ];59:1-11
Available from: https://www.jvbd.org/article.asp?issn=0972-9062;year=2022;volume=59;issue=1;spage=1;epage=11;aulast=Jakhar;type=0