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Early virus clearance of SARS-CoV-2 among co-infection with malaria
Pravin M Rathi, Niraj N Mahajan, Vartika Srivastava, Parmeshwar R Junare, Saurabh Bansal, Nandita Kaushal, Darshana B Rathod
B.Y.L. Nair Charitable Hospital and Topiwala National Medical College, Mumbai, 400008, Maharashtra
Correspondence Address:
Niraj N Mahajan,
Department of Obstetrics and Gynecology, B.Y.L. Nair Charitable Hospital and T. N. Medical College, Mumbai-400008
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/0972-9062.364758
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Background & objectives: India has witnessed significant number of cases of co-infection of malaria or dengue with COVID-19, especially during monsoon season. It has been speculated that anti-malarial immunity might have a protective role in co-infection. Retrospective analysis of co-infection of vector borne diseases with COVID-19 was done for comparing their remission with matched controls with COVID-19 by means of epidemiological data.
Methods: Medical case records of patients with Co-infection of Malaria or dengue with COVID-19 admitted at TNMC and BYL Nair Charitable Hospital, Mumbai the first dedicated COVID-19 hospital in India, from 1st March 2020 to 31st October 2020 were analyzed retrospectively. Out of 91 cases of co-infection of SARS-CoV-2 infection with vector-borne diseases, virus clearance (VC) analysis was done for 61 co-infections with malaria.
Results: Median duration of VC for co-infection with malaria was 8 days whereas, it was 12 days for controls with COVID-19 (p=0.056). Young patients (≤50 years) with co-infection recovered faster than controls age (p=0.018).
Interpretation & conclusion: Co-infection with malaria is associated with less severe disease and early recovery in the form of early VC. Genetic and immunological studies are necessary to confirm malaria protection against SARS-CoV-2 infection. |
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