• Users Online: 181
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
 
ORIGINAL ARTICLE
Ahead of Print

Global status of Anaplasma phagocytophilum infections in human population: results of a 50-year (1970-2020) meta-analysis


1 Department of Veterinary Public Health and Preventive Medicine, Federal University of Agriculture Zuru, PMB 28 Zuru, Kebbi State, Nigeria
2 Department of Veterinary Parasitology and Entomology, Federal University of Agriculture Zuru, PMB 28 Zuru, Kebbi State, Nigeria
3 Department of Zoology, Federal University Lafia, PMB 146 Lafia, Nasarawa State, Nigeria

Correspondence Address:
Solomon Ngutor Karshima,
Department of Veterinary Public Health and Preventive Medicine, Federal University of Agriculture Zuru, PMB 28 Zuru, Kebbi State
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-9062.364756

Background & objectives: Anaplasma phagocytophilum causes human granulocytic anaplasmosis; a febrile tick-borne bacterial zoonosis of increasing public health importance in many parts of the world which is life threatening in undiagnosed, misdiagnosed and untreated cases. We determined and reported in this study the global status of the pathogen in man. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was used to perform a systematic review and meta-analysis of data published in six electronic databases between 1970 and 2020. We pooled data using the random-effects model, performed sensitivity analysis by the single study deletion method and assess across study bias by the funnel plot and its statistical significance by the Egger's regression test. Results: A total of 7018 cases of A. phagocytophilum were reported from 48,619 individuals examined across 22 countries in three continents. Overall pooled estimate was 8.13% (95% CI: 5.70 - 11.47) with a range of 4.64 (95% CI: 1.78 - 11.54) to 12.18% (95% CI: 7.66 - 18.83) across sub-groups. Regional prevalence was highest in North America 11.07% (95% CI: 3.13 - 32.38), while that in relation to study population was highest among occupationally exposed population 11.41% (95% CI: 5.69 - 21.56). Interpretation & conclusion: The study revealed a significant variation in the prevalence of A. phagocytophilum across Asia, Europe and North America, with the highest prevalence in North America and among occupationally exposed population. To curtail the menace of this growing public health crisis, we recommend integrated control programmes involving tick control, the use of appropriate clothing by occupationally exposed population and health education.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Karshima SN
    -  Ahmed MI
    -  Mohammed KM
    -  Pam VA
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed147    
    PDF Downloaded0    

Recommend this journal