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CASE REPORT
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Molecular characterization of the severe falciparum malaria with typhoid co-infection: A case report


1 Cell Biology Laboratory and Malaria Parasite Bank, ICMR-National Institute of Malaria Research, New Delhi, India
2 Department of Microbiology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India
3 Department of Pediatric, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India
4 Department of Biotechnology, Kumaun University, Nainital, Uttarakhand, India

Correspondence Address:
Vineeta Singh,
Cell Biology Laboratory and Malaria Parasite Bank, ICMR-National Institute of Malaria Research, New Delhi
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-9062.331416

Malaria and typhoid co-infections can be a serious public health issue in tropical countries leading to incorrect diagnosis due to overlapping clinical presentations of malaria and typhoid and hence, causing a delay in implementing the appropriate treatment regimen for these concurrent infections. This study reports a case of six-year-old female child co-infected with severe malaria (Plasmodium falciparum) and typhoid (Salmonella typhi) diagnosed by rapid malaria antigen test (RMAT) and blood culture respectively. Further, analysis of the chloroquine resistance gene Pfcrt for the falciparum demonstrated the presence of K76T mutant allele in pfcrt gene with high IC 50 (150nM) for chloroquine (CQ) drug. The present case highlights the significance of timely identification and treatment of co-infections and also provides information about the circulating P. falciparum clinical strains.


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