The Expression of the miR-193, miR-122 and miR-155 profiling and evaluation the serum lipid in antimony-susceptible and resistance patients with Cutaneous Leishmaniasis Rahvar F, Jouni FJ, Abdollahi A, Samei A, Moslemi M, Vazini H, - J Indian Prosthodont Soc

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The Expression of the miR-193, miR-122 and miR-155 profiling and evaluation the serum lipid in antimony-susceptible and resistance patients with Cutaneous Leishmaniasis Farzaneh Rahvar¹, Fatemeh Javani Jouni², Abbas Abdollahi³, Azam Samei⁴, Masoumeh Moslemi⁵, Hossein Vazini⁶ ¹ Department of Medical Genetics, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran ² Department of Biomedical Engineering, Faculty of Health, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran ³ Department of Microbiology, Fasa University of Medical Sciences Fasa, Fars, Iran ⁴ Department of Laboratory Sciences, School of Allied Medical Sciences, Kashan University of Medical Sciences, Iran ⁵ Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran ⁶ Nursing Department, Basic Sciences faculty, Hamedan Branch, Islamic Azad University, Hamedan, Iran Correspondence Address: Hossein Vazini, Nursing Department, Basic Sciences faculty, Hamedan Branch, Islamic Azad University, Hamedan Iran Source of Support: None, Conflict of Interest: None DOI: 10.4103/0972-9062.328816

Aim & objectives: Current investigation was carried out to evaluate the expression of the miR-193, miR-122 and miR-155 and also lipid profile in antimony-susceptible and resistance patients with Cutaneous leishmaniasis. Methods: Lesion and blood samples were collected from 27 antimony-resistance and 27 antimony-susceptible patients. mRNA were extracted and synthase to the cDNA using commercial kits according to the manufactures guideline. The expression of miR-193, miR-122 and miR-155 were evaluated using Real Time PCR technique. The serum lipid profiles were measured by enzymatic methods. Results: Our results indicated that the expression of the miR-193, miR-122 and miR-155 were significantly higher in antimony-susceptible patients. The results of current study indicated that downregulation of miRNAs are coupled with low serum LDL-C and triglyceride. Interpretation & Conclusion: It can be concluded that downregulation of miRNAs and decrease in lipid levels may be one of the mechanisms of parasite to escape from host immune system.

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    -  Rahvar F
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    -  Abdollahi A
    -  Samei A
    -  Moslemi M
    -  Vazini H

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