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Year : 2017  |  Volume : 54  |  Issue : 1  |  Page : 35-43

Seroprevalence and clinical manifestations of Chikungunya virus infection in rural areas of Chandrapur, Maharashtra, India

1 Biochemistry Research Centre, Central India Institute of Medical Sciences, Nagpur, Maharashtra, India
2 Guru Nanak College of Science, Chandrapur, Maharashtra, India

Correspondence Address:
Rajpal S Kashyap
Biochemistry Research Laboratory, Central India Institute of Medical Sciences, 88/2, Bajaj Nagar, Nagpur–440 010, Maharashtra
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Source of Support: None, Conflict of Interest: None

PMID: 28352044

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Background & objectives: Chikungunya virus (CHIKV) infection has recently witnessed re-emergence, affecting rural areas of India with high morbidity rates. This prospective study was conducted to evaluate seroprevalence and clinical manifestation in targeted villages reporting cases of CHIKV infection. Methods: A total of482 patients were recruited from Kalmana and Kothari villages of Ballarpur; Chandrapur district of Maharashtra state, India during CHIKV outbreaks in 2011–12. The serum samples from infected CHIKV patients were simultaneously screened through ELISA for detection of antigen and antibodies (IgM and IgG). Chi-square analysis was used to evaluate differences in seropositivity between age, gender and clinical manifestations of CHIKV. Results: Out of 482 enrolled participants, 197 (41%) males and 285 (59%) females were aged between 5 and 92 yr. The clinical manifestations such as small joint pain (80%), neck stiffness (75%), fever (49%) and large joint pain (47%) were observed amongst CHIKV infected subjects. Mucocutaneous rashes (91%) on knees (71%), feet (56%), fingers and palms (54%) were also observed. Overall, seroprevalence of CHIKV infection was found to be 46% in infected participants during the epidemic period. Among risk factors, ageing and female gender was strongly associated with a raised seroprevalence of CHIKV infection along with symptoms such as rashes, small joints pain and neck stiffness. Interpretation & conclusion: This study reported high seroprevalence rates of CHIKV infection in targeted populations, suggesting its re-emergence in rural India. Proper surveillance is, therefore, necessary to minimize re-emergence and in controlling these impending and sporadic outbreaks.

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